Journal
TRENDS IN NEUROSCIENCES
Volume 45, Issue 2, Pages 145-157Publisher
CELL PRESS
DOI: 10.1016/j.tins.2021.11.006
Keywords
-
Categories
Ask authors/readers for more resources
This review discusses the significance of the alpha 7 nicotinic acetylcholine receptor (nAChR) in the hippocampus and its association with cognitive dysfunction, as well as highlighting approaches to improve therapeutic development.
Cholinergic innervation of the hippocampus uses the neurotransmitter acetylcholine (ACh) to coordinate neuronal circuit activity while simultaneously influencing the function of non-neuronal cell types. The alpha 7 nicotinic ACh receptor (nAChR) subtype is highly expressed throughout the hippocampus, has the highest calcium permeability compared with other subtypes of nAChRs, and is of high therapeutic interest due to its association with a variety of neurological disorders and neurodegenerative diseases. In this review, we synthesize research describing alpha 7 nAChR properties, function, and relationship to cognitive dysfunction within the hippocampal circuit and highlight approaches to help improve therapeutic development.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available