Journal
TRENDS IN MOLECULAR MEDICINE
Volume 27, Issue 12, Pages 1106-1114Publisher
CELL PRESS
DOI: 10.1016/j.molmed.2021.09.005
Keywords
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Funding
- Canada Research Chair
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Neurodevelopmental disorders may be caused in part by deficits in epigenetic priming, which prepares the genome for cellular signaling cues and may lead to impairment of terminally differentiated cells. High-resolution epigenetic and transcriptomic mapping studies provide evidence supporting this theory.
Neurodevelopmental disorders (NDDs) affect about 1% of the population and can be caused by mutations in genes that affect the epigenetic code. There is limited functional understanding of most of these epigenetic modifiers, and we suggest that associated NDDs are caused, in part, by deficits in epigenetic priming, a prepatterning step that alters the genome in preparation to make cells competent to signaling cues. We provide evidence from high-resolution epigenetic and transcriptomic mapping studies to demonstrate how a failure to adequately prime the genome for neural induction could lead to impairment of terminally differentiated cells. This idea provides a framework for NDD pathogenesis and treatment.
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