Journal
TRENDS IN MICROBIOLOGY
Volume 29, Issue 10, Pages 869-870Publisher
CELL PRESS
DOI: 10.1016/j.tim.2021.07.005
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Funding
- National Science Foundation (NSF) [1838327]
- Direct For Biological Sciences
- Division Of Environmental Biology [1838327] Funding Source: National Science Foundation
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A recent study introduces a novel RNA-based Cas-dependent toxin-antitoxin system that has the ability to 'addict' cells to a specific genetic cassette. The broader concept of addiction systems could potentially stabilize various genomic features, leading to questions regarding the role of selfish elements and intragenomic conflict in the evolution of biological complexity.
A recent paper (Li et al.) reports a novel RNA-based Cas-dependent toxin-antitoxin system with the effect of 'addicting' cells to the cassette. Broadly-defined addiction systems could stabilize diverse genomic features, raising the question of the role of selfish elements and intragenomic conflict in the evolution of biological complexity.
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