4.7 Review

Targeting bacterial outer-membrane remodelling to impact antimicrobial drug resistance

Related references

Note: Only part of the references are listed.
Article Microbiology

Bacteriophage-resistant Acinetobacter baumannii are resensitized to antimicrobials

Fernando Gordillo Altamirano et al.

Summary: The study found that the bacterial capsule of Acinetobacter baumannii serves as the receptor for the phages phi FG02 and phi CO01. Mutants resistant to the phages had mutations in genes responsible for capsule biosynthesis, leading to loss of capsule and disruption of phage adsorption. These phage-resistant strains showed decreased susceptibility to human complement, beta-lactam antibiotics, and alternative phages, and exhibited reduced fitness in vivo. Furthermore, phage therapy was effective in treating A. baumannii infection in a mouse model.

NATURE MICROBIOLOGY (2021)

Review Chemistry, Multidisciplinary

How to Enter a Bacterium: Bacterial Porins and the Permeation of Antibiotics

Jigneshkumar Dahyabhai Prajapati et al.

Summary: Traditional antibiotics are facing the challenge of Gram-negative bacteria developing resistance, prompting the urgent need for new antibacterial agents. Designing new antibiotic molecules that can rapidly penetrate Gram-negative bacteria and achieve lethal intracellular drug accumulation is a major challenge. The lack of simple experimental techniques to measure antibiotic uptake and local concentrations in subcellular compartments is a limiting factor.

CHEMICAL REVIEWS (2021)

Review Biochemical Research Methods

Unlocking the next generation of phage therapy: the key is in the receptors

Fernando L. Gordillo Altamirano et al.

Summary: Understanding the function and location of phage receptors is crucial for improving and innovating the use of phage therapy. This can lead to the design of intelligent phage cocktails, discovery of new phage-derived antimicrobials, and guiding the evolution of phage resistance towards clinically exploitable phenotypes.

CURRENT OPINION IN BIOTECHNOLOGY (2021)

Review Microbiology

A ban on BAM: an update on inhibitors of the β-barrel assembly machinery

Maurice Steenhuis et al.

Summary: Gram-negative pathogens pose a growing threat to global health due to high rates of antibiotic resistance and lack of novel antibiotics. Efforts targeting the β-barrel assembly machine (BAM) complex have shown significant progress in the development of new antibiotics.

FEMS MICROBIOLOGY LETTERS (2021)

Article Biochemistry & Molecular Biology

The big BAM theory: An open and closed case?

Runrun Wu et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2020)

Editorial Material Biochemistry & Molecular Biology

The Fellowship of the Rings: Macrocyclic Antibiotic Peptides Reveal an Anti-Gram-Negative Target

Martin I. McLaughlin et al.

BIOCHEMISTRY (2020)

Article Microbiology

New Multidrug Efflux Inhibitors for Gram-Negative Bacteria

Robert L. Marshall et al.

Article Chemistry, Medicinal

cryoEM-Guided Development of Antibiotics for Drug-Resistant Bacteria

Matthew J. Belousoff et al.

CHEMMEDCHEM (2019)

Review Infectious Diseases

Global economic impact of antibiotic resistance: A review

Mohammad Ahmad et al.

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2019)

Article Multidisciplinary Sciences

Chimeric peptidomimetic antibiotics against Gram-negative bacteria

Anatol Luther et al.

NATURE (2019)

Review Microbiology

Phage Therapy in the Postantibiotic Era

Fernando L. Gordillo Altamirano et al.

CLINICAL MICROBIOLOGY REVIEWS (2019)

Article Infectious Diseases

Porin Deficiency in Carbapenem-Resistant Enterobacter aerogenes Strains

Min Hao et al.

MICROBIAL DRUG RESISTANCE (2018)

Review Microbiology

Bacterial machineries for the assembly of membrane-embedded beta-barrel proteins

David Ranava et al.

FEMS MICROBIOLOGY LETTERS (2018)

Review Biotechnology & Applied Microbiology

Improving E. coli growth performance by manipulating small RNA expression

Alejandro Negrete et al.

MICROBIAL CELL FACTORIES (2017)

Article Biochemistry & Molecular Biology

Multidrug-resistant bacteria compensate for the epistasis between resistances

Jorge Moura de Sousa et al.

PLOS BIOLOGY (2017)

Article Biochemistry & Molecular Biology

Molecular Basis of Filtering Carbapenems by Porins from β-Lactam-resistant Clinical Strains of Escherichia coli

Harsha Bajaj et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Review Biochemistry & Molecular Biology

The Function of the DegP (HtrA) Protein: Protease Versus Chaperone

Zengyi Chang

IUBMB LIFE (2016)

Review Biochemistry & Molecular Biology

From Chaperones to the Membrane with a BAM!

Ashlee M. Plummer et al.

TRENDS IN BIOCHEMICAL SCIENCES (2016)

Review Microbiology

Carbapenemase-Producing Klebsiella pneumoniae, a Key Pathogen Set for Global Nosocomial Dominance

Johann D. D. Pitout et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)

Review Biology

Outer membrane protein biogenesis in Gram-negative bacteria

Sarah E. Rollauer et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2015)

Article Biochemistry & Molecular Biology

Everything old is new again: An update on current research on the Cpx envelope stress response

Tracy L. Raivio

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2014)

Article Biochemistry & Molecular Biology

Structure-kinetic relationship of carbapenem antibacterials permeating through E-coli OmpC porin

Que-Tien Tran et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2014)

Review Microbiology

Adaptive and Mutational Resistance: Role of Porins and Efflux Pumps in Drug Resistance

Lucia Fernandez et al.

CLINICAL MICROBIOLOGY REVIEWS (2012)

Article Microbiology

OmpK26, a Novel Porin Associated with Carbapenem Resistance in Klebsiella pneumoniae

Laur Garcia-Sureda et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)

Review Microbiology

Metabolic regulation of antibiotic resistance

Jose L. Martinez et al.

FEMS MICROBIOLOGY REVIEWS (2011)

Review Biotechnology & Applied Microbiology

The Complexities of Porin Genetic Regulation

Miguel Angel De la Cruz et al.

JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY (2010)

Article Multidisciplinary Sciences

A Modular BAM Complex in the Outer Membrane of the α-Proteobacterium Caulobacter crescentus

Khatira Anwari et al.

PLOS ONE (2010)

Article Multidisciplinary Sciences

Peptidomimetic Antibiotics Target Outer-Membrane Biogenesis in Pseudomonas aeruginosa

Nityakalyani Srinivas et al.

SCIENCE (2010)

Review Microbiology

The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria

Jean-Marie Pages et al.

NATURE REVIEWS MICROBIOLOGY (2008)

Article Biochemistry & Molecular Biology

Protein complexes of the Escherichia coli cell envelope

F Stenberg et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Infectious Diseases

Overexpression of the multidrug efflux pump SmeDEF impairs Stenotrophomonas maltophilia physiology

A Alonso et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2004)

Article Microbiology

MicC, a second small-RNA regulator of Omp protein expression in Escherichia coli

S Chen et al.

JOURNAL OF BACTERIOLOGY (2004)