Viral manipulation of host cell necroptosis and pyroptosis

Cell death forms an essential component of the antiviral immune response. Viral infection elicits different forms of host cell death, including the lytic and inflammatory cell death modes necroptosis or pyroptosis. The induction of both types of cell death not only eliminates virus-infected cells but also contributes to the development of innate and adaptive immunity through the release of inflammatory mediators. The importance of necroptosis and pyroptosis in host defence is evident from the numerous viral evasion mechanisms that suppress these cell death pathways. Here, we review the emerging principles by which viruses antagonise host cell necroptosis and pyroptosis to promote their spread and block host immunity.

Automated summary

Cell death, including necroptosis and pyroptosis, is an important part of the antiviral immune response, eliminating virus-infected cells and promoting immune development through the release of inflammatory mediators. Viruses employ evasion mechanisms to suppress these cell death pathways and antagonize host immunity.