Journal
TRENDS IN MICROBIOLOGY
Volume 30, Issue 6, Pages 593-605Publisher
CELL PRESS
DOI: 10.1016/j.tim.2021.11.011
Keywords
-
Categories
Funding
- Research Foundation Flanders (FWO)
- EOS MODEL-IDI (FWO) [30826052]
- FWO [G.0E04.16N, G.0C76.18N, G.0B71.18N, G.0B96.20N]
- Foundation against Cancer [F/2016/865, F/2020/1505]
- Methusalem [BOF16/MET_V/007]
- CRIG
- GIGG consortia
- Research Foundation Flanders [G0H8618N]
- Ghent University
Ask authors/readers for more resources
Cell death, including necroptosis and pyroptosis, is an important part of the antiviral immune response, eliminating virus-infected cells and promoting immune development through the release of inflammatory mediators. Viruses employ evasion mechanisms to suppress these cell death pathways and antagonize host immunity.
Cell death forms an essential component of the antiviral immune response. Viral infection elicits different forms of host cell death, including the lytic and inflammatory cell death modes necroptosis or pyroptosis. The induction of both types of cell death not only eliminates virus-infected cells but also contributes to the development of innate and adaptive immunity through the release of inflammatory mediators. The importance of necroptosis and pyroptosis in host defence is evident from the numerous viral evasion mechanisms that suppress these cell death pathways. Here, we review the emerging principles by which viruses antagonise host cell necroptosis and pyroptosis to promote their spread and block host immunity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available