Fostering experimental and computational synergy to modulate hyperinflammation

The molecular underpinnings of the uncontrolled release of proinflammatory cytokines and chemokines ('cytokine storm'), which can cause organ damage and even mortality, are not completely understood. Furthermore, targeted therapeutic options to dampen such hyperinflammation are scarce. Here, we highlight the ways in which technological advances have set the stage for a new age of synergy between experimental and computational researchers to guide the discovery of novel therapeutic targets for modulating hyperinflammation.

Automated summary

This article highlights the opportunities brought by technological advances for collaboration between experimental and computational researchers in order to discover new therapeutic targets for modulating hyperinflammation.