Journal
TRENDS IN IMMUNOLOGY
Volume 42, Issue 12, Pages 1113-1127Publisher
CELL PRESS
DOI: 10.1016/j.it.2021.10.004
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Funding
- National Health and Medical Research Council of Australia [1196235, 1155342]
- Melbourne research scholarship
- National Health and Medical Research Council of Australia [1155342, 1196235] Funding Source: NHMRC
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DCs, particularly cDC1s, play a crucial role in orchestrating protective immune responses against pathogens or cancers, with recent studies highlighting their importance in tumor immunotherapy. The unique ability of cDC1s to promote cytotoxic CD8+ T cell differentiation makes them a promising target for enhancing anticancer immunity.
Dendritic cells (DCs) are key immune sentinels that orchestrate protective im-mune responses against pathogens or cancers. DCs have evolved into multiple phenotypically, anatomically, and functionally distinct cell types. One of these DC types, Type 1 conventional DCs (cDC1s), are uniquely equipped to promote cytotoxic CD8+ T cell differentiation and, therefore, represent a promising target for harnessing antitumor immunity. Indeed, recent studies have highlighted the importance of cDC1s in tumor immunotherapy using immune checkpoint inhibitors. Here, we review the progress in defining the key developmental and functional attributes of cDC1s and the approaches to optimizing the potency of cDC1s for anticancer immunity.
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