Journal
TRENDS IN IMMUNOLOGY
Volume 42, Issue 11, Pages 945-947Publisher
CELL PRESS
DOI: 10.1016/j.it.2021.09.012
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Funding
- National Natural Science Foundation of China [31770937, 31970892, 81788101]
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Living organisms have developed conserved mechanisms for detecting and responding to molecular patterns from invading viruses, with cGAS-like receptors being a newly identified family of PRRs specifically for viral nucleic acids.
Living organisms have evolved conserved 'catchers' for detecting and handling molecular patterns from invading viruses. Slavik et al. and Holleufer et al. recently identified cyclic GMP-AMP (cGAMP) synthase (cGAS)- like receptors that detect double-stranded viral RNA in Drosophila. cGAS-like receptors constitute a newexpanding family of pattern recognition receptors (PRRs) for viral nucleic acids.
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