Th17 cells: from gut homeostasis to CNS pathogenesis

Th17 cells play crucial roles in host-microbe interactions, but can also promote chronic inflammation and tissue pathology. Factors influencing Th17 cell heterogeneity and effector functions in different inflammatory contexts remain unclear. Schnell et al. demonstrate that intestinal Th17 cells form a reservoir from which pathogenic Th17 cells can be elicited during severe tissue inflammation.

Automated summary

Th17 cells play crucial roles in host-microbe interactions and can also contribute to chronic inflammation and tissue pathology. This study reveals that intestinal Th17 cells serve as a reservoir for pathogenic Th17 cells during severe tissue inflammation.