Journal
TRENDS IN GENETICS
Volume 37, Issue 10, Pages 865-867Publisher
CELL PRESS
DOI: 10.1016/j.tig.2021.06.001
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Decoding human variants of uncertain significance (VUSs) through feline genomic medicine is possible. Telomere-to-telomere genome assemblies in all felid species support genetic evolution and speciation studies. The highly conserved genomic organization in cats compared to humans suggests they may also decipher intergenic variations affecting 3D chromosome structures influencing gene regulation.
Feline genomic medicine can decode human variants of uncertain significance (VUSs). Telomere-to-telomere genome assemblies are feasible for all felid species, supporting genetic evolution and speciation studies. Their highly conserved genomic organization compared to humans suggests cats may also decipher the intergenic variation affecting the 3D chromosome structures influencing gene regulation.
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