Journal
TRENDS IN GENETICS
Volume 38, Issue 4, Pages 379-394Publisher
CELL PRESS
DOI: 10.1016/j.tig.2021.10.002
Keywords
-
Categories
Funding
- Charite -Universitatsmedizin Berlin
- Berlin Institute of Health
- Northern Norway Regional Health Authority [HNF1585-21]
- National Institutes of Health (NIH/NCATS) through the NIH Common Fund, Office of Strategic Coordination (OSC) [UH3TR00943]
- NCI [1R01 CA182905-01, 1R01CA222007-01A1]
- NIGMS [1R01GM122775-01]
- Department of Defense [CA160445P1]
- Chronic Lymphocytic Leukemia Moonshot Flagship project
- CLL Global Research Foundation 2019 grant
- CLL Global Research Foundation 2020 grant
- Estate of C.G. Johnson, Jr.
Ask authors/readers for more resources
This article summarizes the important role of miRNAs in cancer, with a particular focus on the less studied mechanisms of regulation in cancer.
Alterations in microRNAs (miRNAs) expression are causative in the initiation and progression of human cancers. The molecular events responsible for the wide-spread differential expression of miRNAs in malignancy are exemplified by their location in cancer-associated genomic regions, epigenetic mechanisms, transcrip-tional dysregulation, chemical modifications and editing, and alterations in miRNA biogenesis proteins. The classical miRNA function is synonymous with post-transcriptional repression of target protein genes. However, several studies have reported miRNAs functioning outside this paradigm and some of these novel modes of regulation of gene expression have been implicated in cancers. Here, we summarize key aspects of miRNA involvement in cancer, with a special focus on these lesser-studied mechanisms of action.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
