Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 33, Issue 1, Pages 18-35Publisher
CELL PRESS
DOI: 10.1016/j.tem.2021.10.005
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Funding
- Fonds de Recherche du Quebec Sante (FRQS)
- Japan Society for the Promotion of Science (JSPS)
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Obesity exacerbates the incidence of depression and anxiety, mainly due to poor diet and lack of physical activity, resulting in metabolic and vascular dysfunction that affects neural status and mood.
The incidence of depression and anxiety is amplified by obesity. Mounting evidence reveals that the psychiatric consequences of obesity stem from poor diet, inactivity, and visceral adipose accumulation. Resulting metabolic and vascular dysfunction, including inflammation, insulin and leptin resistance, and hypertension, have emerged as key risks to depression and anxiety development. Recent research advancements are exposing the important contribution of these different corollaries of obesity and their impact on neuroimmune status and the neural circuits controlling mood and emotional states. Along these lines, this review connects the clinical manifestations of depression and anxiety in obesity to our current understanding of the origins and biology of immunometabolic threats to central nervous system function and behavior.
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