Journal
TRENDS IN BIOTECHNOLOGY
Volume 40, Issue 7, Pages 816-830Publisher
CELL PRESS
DOI: 10.1016/j.tibtech.2021.12.002
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Funding
- National Natural Science Foundation of China (NSFC) [U20A20212, U1730138, U1730246, 1930123, 61771327, 11704358]
- Distinguished Young Scholars of Sichuan Province [2020JDJQ0008]
- Foundation of President of China Academy of Engineering Physics [YZJJLX2018001]
- Fundamental Research Funds for Central Universities
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In this review, the authors discuss the research progress of Terahertz (THz) medical imaging for in vivo applications. They focus on the development of imaging contrast agents and novel imaging methods suitable for living organisms, and propose a roadmap for taking THz medical imaging from in vitro to in vivo.
Terahertz (THz) radiation has attracted considerable attention in medical imaging owing to its nonionizing and spectral fingerprinting characteristics. To date, most studies have focused on in vitro and ex vivo objects with water-removing pretreatment because the water in vivo excessively absorbs the THz waves, which causes deterioration of the image quality. In this review, we discuss how THz medical imaging can be used for a living body. The development of imaging contrast agents has been particularly useful to this end. In addition, we also introduce progress in novel THz imaging methods that could be more suitable for in vivo applications. Based on our discussions, we chart a developmental roadmap to take THz medical imaging from in vitro to in vivo.
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