Journal
TRANSPLANT INFECTIOUS DISEASE
Volume 24, Issue 2, Pages -Publisher
WILEY
DOI: 10.1111/tid.13788
Keywords
clinical effectiveness; COVID-19 vaccine; SARS-CoV-2; solid organ transplant
Categories
Funding
- Cystic Fibrosis Foundation [ASLAM20A0-I]
- National Institute of Allergy and Infectious Diseases [R3761154]
- Center for AIDS Research, University of California, SanDiego [AI036214]
- National Center forAdvancing Translational Sciences [UL1TR001442]
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This study examined the clinical effectiveness of COVID-19 vaccination in solid organ transplant recipients. The results showed that receiving two doses of mRNA COVID-19 vaccines provided significant protection against symptomatic COVID-19.
Background Clinical effectiveness of coronavirus disease 2019 (COVID-19) vaccination in solid organ transplant recipients (SOTRs) is not well documented despite multiple studies demonstrating sub-optimal immunogenicity. Methods We reviewed medical records of eligible SOTRs at a single center to assess vaccination status and identify cases of symptomatic COVID-19 from January 1 to August 12, 2021. We developed a Cox proportional hazards model using the date of vaccination and time since transplantation as a time-varying covariate with age and gender as potential time-invariant confounders. Survival curves were created using the parameters estimated from the Cox model. Results: Among 1904 SOTRs, 1362 were fully vaccinated (96% received mRNA vaccines) and 542 were either unvaccinated (n = 470) or partially vaccinated (n = 72). There were 115 cases of COVID-19, of which 12 occurred in fully vaccinated individuals. Cox regression with the date of vaccination and time since transplantation as the time-varying co-variates showed that after baseline adjustment for age and sex, being fully vaccinated had a significantly lower hazard for COVID-19, hazard ratio (HR) = 0.29 and 95% confidence interval ([CI] 0.09, 0.91). Conclusion We found that 2-dose mRNA COVID-19 vaccination was protective of symptomatic COVID-19 in vaccinated versus unvaccinated SOTRs. Tweet COVID-19 vaccination was associated with a significantly lower hazard for symptomatic COVID-19 (HR 0.29; 95% CI 0.09, 0.91) among 1904 SOT recipients at a single center from January 1 to August 12, 2021.
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