4.5 Article

Effective killing of cells expressing CD276 (B7-H3) by a bispecific T cell engager based on a new fully human antibody

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Preclinical assessment of the efficacy and specificity of GD2-B7H3 SynNotch CAR-T in metastatic neuroblastoma

Babak Moghimi et al.

Summary: The study highlights the importance of developing gated systems for predicting clinical toxicity of CAR T cells in solid tumors. By utilizing murine and human CAR-T cells specific for tumor antigens, the researchers were able to generate a GD2-B7H3 CAR-T with improved metabolic fitness and efficacy in controlling neuroblastoma growth in preclinical models. This innovative approach shows promising results in suppressing neuroblastoma with minimal adverse effects.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

B7-H3x4-1BB bispecific antibody augments antitumor immunity by enhancing terminally differentiated CD8+ tumor-infiltrating lymphocytes

Gihoon You et al.

Summary: The bispecific antibody B7-H3x4-1BB effectively restricts 4-1BB stimulation in tumors and elicits a 4-1BB-dependent antitumor response, primarily targeting CD8 T cells for increased proliferation and cytokine production. Combination therapy with PD-1 blockade further enhances this antitumor activity by increasing terminally differentiated CD8 T cells, providing an effective and safe treatment option for B7-H3-positive cancers.

SCIENCE ADVANCES (2021)

Article Oncology

The B7-H3-Targeting Antibody-Drug Conjugate m276-SL-PBD Is Potently Effective Against Pediatric Cancer Preclinical Solid Tumor Models

Nathan M. Kendsersky et al.

Summary: The study demonstrates significant antitumor activity of the B7-H3-targeting antibody-drug conjugate in pediatric solid tumor PDX models, showing a positive response across various cancer types.

CLINICAL CANCER RESEARCH (2021)

Article Oncology

Targeting B7-H3 via chimeric antigen receptor T cells and bispecific killer cell engagers augments antitumor response of cytotoxic lymphocytes

Jie Liu et al.

Summary: The study demonstrates that using B7-H3 CAR-T cells and B7-H3/CD16 BiKE can effectively inhibit NSCLC tumor growth, and direct CD16 signaling can significantly increase NK cell activity and target cell death. Additionally, inhibition of B7-H3 may alter tumor glucose metabolism via the reactive oxygen species-mediated pathway.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

Article Oncology

Tumor B7-H3 expression in diagnostic biopsy specimens and survival in patients with metastatic prostate cancer

Gulanbar Amori et al.

Summary: High B7-H3 expression in diagnostic biopsy specimens is independently associated with high disease-specific mortality and overall mortality rates in patients with metastatic prostate cancer. Therefore, tumor B7-H3 expression in diagnostic biopsy specimens may serve as a useful biomarker for identifying highly aggressive metastatic prostate cancer.

PROSTATE CANCER AND PROSTATIC DISEASES (2021)

Letter Biochemistry & Molecular Biology

Administration of B7-H3 targeted chimeric antigen receptor-T cells induce regression of glioblastoma

Xin Tang et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Review Biochemistry & Molecular Biology

B7-H3 Immune Checkpoint Protein in Human Cancer

Karine Flem-Karlsen et al.

CURRENT MEDICINAL CHEMISTRY (2020)

Letter Biotechnology & Applied Microbiology

Visualizing and interpreting cancer genomics data via the Xena platform

Mary J. Goldman et al.

NATURE BIOTECHNOLOGY (2020)

Article Biochemistry & Molecular Biology

Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors

Johanna Theruvath et al.

NATURE MEDICINE (2020)

Review Oncology

Alternative Checkpoints as Targets for Immunotherapy

Ayush Pant et al.

CURRENT ONCOLOGY REPORTS (2020)

Review Biochemistry & Molecular Biology

B7-H3, a checkpoint molecule, as a target for cancer immunotherapy

Shuo Yang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2020)

Article Oncology

B7-H3 Negatively Modulates CTL-Mediated Cancer Immunity

Kimio Yonesaka et al.

CLINICAL CANCER RESEARCH (2018)

Review Pharmacology & Pharmacy

T cell engaging bispecific antibody (T-BsAb): From technology to therapeutics

Z. Wu et al.

PHARMACOLOGY & THERAPEUTICS (2018)

Review Oncology

B7H3 As a Promoter of Metastasis and Promising Therapeutic Target

Peixin Dong et al.

FRONTIERS IN ONCOLOGY (2018)

Review Immunology

The future of immune checkpoint cancer therapy after PD-1 and CTLA-4

Andrew W. Hahn et al.

IMMUNOTHERAPY (2017)

Article Cell Biology

B7-H3 Overexpression Predicts Poor Survival of Cancer Patients: A Meta-Analysis

Zhimeng Ye et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2016)

Article Biochemistry & Molecular Biology

Humanized Affinity-matured Monoclonal Antibody 8H9 Has Potent Antitumor Activity and Binds to FG Loop of Tumor Antigen B7-H3

Mahiuddin Ahmed et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Biochemistry & Molecular Biology

Structure and T Cell Inhibition Properties of B7 Family Member, B7-H3

Vladimir Vigdorovich et al.

STRUCTURE (2013)

Review Biotechnology & Applied Microbiology

Pharmacokinetic, pharmacodynamic and immunogenicity comparability assessment strategies for monoclonal antibodies

Wendy S. Putnam et al.

TRENDS IN BIOTECHNOLOGY (2010)

Editorial Material Multidisciplinary Sciences

The contrasting role of B7-H3

Kimberly A. Hofmeyer et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)