Powassan virus: What is the risk to the blood supply?

Powassan virus (POWV) is an emerging tick-borne arbovirus that is found widely in Canada, the Northeastern and Northcentral United States, and the Russian Far East. While still rare, there has been an increase in reported cases of POWV disease over the last decade; most (>90%) cases have been neuroinvasive and the associated fatality rate is high (>10%). Transfusion-associated risk of POWV remains uncertain; while no intervention is likely indicated, one probable case of transfusion-transmitted POWV in the context of an increase in the incidence of POWV and other tick-borne infections, merits vigilance.

Automated summary

Powassan virus (POWV) is an emerging tick-borne arbovirus that has seen an increase in reported cases, with a high fatality rate for neuroinvasive cases. The risk of transfusion-associated transmission remains uncertain, but vigilance is necessary amidst the rise in cases.