Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 150, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2022.116569
Keywords
MALDI-TOF-MS; Virus; COVID-19; Detection; Identification; Improvisations
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This review evaluates the application of MALDI TOF-MS in clinical pathogens and highlights its milestones and shortcomings in COVID-19 analysis. It emphasizes the importance of MALDI-TOF-MS and calls for further scientific attention for COVID-19 analysis.
MALDI-TOF-MS has essentially delivered more than expected with respect to clinical pathogens. Viruses are the most versatile entities of clinical pathogens that have challenged well-established microbiological methodologies. This review evaluates the existing scenario with respect to MALDI TOF-MS analytical technique in the successful analysis of viral pathogens. The milestones achieved with respect to detection and identification of COVID-19 has been presented. The fact that only a handful of scattered applications for COVID-19 exist has been pointed out in the review. Further, the lapses in the utilization of the available state-of-the art MALDI-TOF-MS variants/benchmark sophistications for COVID-19 analysis, are highlighted. When the world is seeking for rapid solutions for early, sensitive, rapid COVID-19 diagnosis, maybe MALDI-TOF-MS, may be the actual 'gold standard'. Reverting to the title, this review emphasizes that there is a need for extrapolating MALDI-TOF-MS for COVID-19 analysis and this calls for urgent scientific attention.(c) 2022 Elsevier B.V. All rights reserved.
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