Monitoring of Promazine in Injection and Dextrose Saline Samples Using Electrochemical Tool Based on Amplified Nanostructure Sensor

Monitoring of pharmaceutical compounds in biological samples is a crucial approach considering the human health. An amplified sensors based on synergic catalytic effect of CdO/SWCNTs nanocomposite and 1,3-dipropylimidazolium bromide (1,3-DPBr) was designed and used for sensing of promazine in the real samples. The catalytic effect of CdO/SWCNTs and 1,3-DPBr at surface of paste electrode creating a powerful tool for monitoring of promazine in a concentration range of 3.0 nM-220 mu M and with a detection limit 0.9 nM acquired by differential pulse voltammetry technique. The oxidation current of promazine was boosted at surface of CdO/SWCNTs/1,3-DPBr/PE about 5.0 fold compared to the unmodified sensor. Recovery data (98.25-102.86%) revealed the superior performance of CdO/SWCNTs/1,3-DPBr/PE for sensing of promazine in the injection and water samples.

Automated summary

A novel amplified sensor based on the synergic catalytic effect of CdO/SWCNTs nanocomposite and 1,3-dipropylimidazolium bromide (1,3-DPBr) was developed for the sensing of promazine in real samples. The sensor exhibited a wide linear range of 3.0 nM-220 μM and a low detection limit of 0.9 nM, achieved using the differential pulse voltammetry technique. The modified sensor showed approximately a 5.0-fold increase in the oxidation current of promazine compared to the unmodified sensor. The recovery data (98.25-102.86%) indicated the excellent performance of the sensor for sensing promazine in injection and water samples.