Journal
TISSUE ENGINEERING PART B-REVIEWS
Volume 28, Issue 5, Pages 978-994Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/ten.teb.2021.0142
Keywords
urine-derived stem cells; tissue engineering; cell therapy; regenerative medicine
Categories
Funding
- National Natural Science Foundation of China [32071331, 31600792]
- Post-Doctor Research Project, West China Hospital, Sichuan University [2018HXBH053]
- 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University [ZYJC18002]
Ask authors/readers for more resources
Regenerative medicine based on stem cell research has the potential to provide advanced health care for human beings. Human urine-derived stem cells (USCs), which are simple, low-cost, and noninvasive to isolate, have shown promising applications in regenerative medicine due to their high expandability and differentiation ability. USCs have shown potential in genitourinary regeneration, musculoskeletal repair, skin wound healing, and disease treatment.
Regenerative medicine based on stem cell research has the potential to provide advanced health care for human beings. Recent studies demonstrate that stem cells in human urine can serve as an excellent source of graft cells for regenerative therapy, mainly due to simple, low-cost, and noninvasive cell isolation. These cells, termed human urine-derived stem cells (USCs), are highly expandable and can differentiate into various cell lineages. They share many biological properties with mesenchymal stem cells, such as potent paracrine effects and immunomodulation ability. The advantage of USCs has motivated researchers to explore their applications in regenerative medicine, including genitourinary regeneration, musculoskeletal repair, skin wound healing, and disease treatment. Although USCs have showed many positive outcomes in preclinical studies, and although the possible applications of USCs for animal therapy have been reported, many issues need to be addressed before clinical translation. This article provides a comprehensive review of USC biology and recent advances in their application for tissue regeneration. Challenges in the clinical translation of USC-based therapy are also discussed. Impact statementRecently, stem cells isolated from urine, referred to as urine-derived stem cells (USCs), have gained much interest in the field of regenerative medicine. Many advantages of human USCs have been found for cell-based therapy: (i) the cell isolation procedure is simple and low cost; (ii) they have remarkable proliferation ability, multidifferentiation potential, and paracrine effects; and (iii) they facilitate tissue regeneration in many animal models. With the hope to facilitate the development of USC-based therapy, we describe the current understanding of USC biology, summarize recent advances in their applications, and discuss future challenges in clinical translation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available