Journal
TISSUE & CELL
Volume 72, Issue -, Pages -Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.tice.2021.101543
Keywords
Exercise; Physical activity; Maternal-fetal interface; Placenta; Pregnancy
Categories
Funding
- Canadian Institutes of Health Research [MOP142298]
- Natural Science and Engineering Research Council [RGPIN-2017-05457]
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Exercise during pregnancy has been shown to have positive effects on the health outcomes of both mother and fetus. While the placenta plays a crucial role in pregnancy, the impact of exercise on placental biology and function is not well understood. Further research is needed to explore the potential benefits of prenatal exercise on placental growth and development.
Exercise during pregnancy has been shown to be associated with improved health outcomes both during and after pregnancy for mother and fetus across the lifespan. Increasing physical activity and reducing sedentary behaviour during pregnancy have been recommended by many researchers and clinicians-alike. It is thought that the placenta plays a central role in mediating any positive or negative pregnancy outcomes. The positive outcomes obtained through prenatal exercise are postulated to result from exercise-induced regulation of maternal physiology and placental development. Considerable research has been performed to understand the placenta's role in pregnancy-related diseases, such as preeclampsia, fetal growth restriction, and gestational diabetes mellitus. However, little research has examined the potential for healthy lifestyle and behavioural changes to improve placental growth, development, and function. While the placenta represents the critical maternal-fetal interface responsible for all gas, nutrient, and waste exchange between the mother and fetus, the impact of exercise during pregnancy on placental biology and function is not well known. This review will focus on prenatal exercise and its promising influence on the structures of the maternal-fetal interface, with particular emphasis on the placenta. Potential molecular mechanistic hypotheses are presented to aid future investigations of prenatal exercise and placental health.
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