4.4 Article

Microwave mediated synthesis of 2-aminooxazoles

Journal

TETRAHEDRON LETTERS
Volume 88, Issue -, Pages -

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2021.153555

Keywords

2-Aminooxazole; Microwave; Heterocycles; Isothiocyanate; beta-Keto azide

Funding

  1. National Science Foundation [1952691]
  2. Direct For Mathematical & Physical Scien
  3. Division Of Chemistry [1952691] Funding Source: National Science Foundation

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A method for the synthesis of 2-aminooxazoles at 150 degrees C using microwave irradiation was developed, providing products with various functional groups in a short reaction time and moderate to good yields, without the need for recrystallization or flash chromatography.
A microwave mediated synthesis of 2-aminooxazoles at 150 degrees C was developed, providing products with a variety of functional groups. The reaction takes 5 min and provides product with a simple precipitation at moderate to good yields without the need for recrystallization or flash chromatography. (C) 2021 The Author(s). Published by Elsevier Ltd.

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