Journal
TETRAHEDRON LETTERS
Volume 91, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2022.153640
Keywords
Natural products; Cytotoxic; Desymmetrization; Wittig olefination; Aldolization; Tethering formation
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Funding
- CSIR, New Delhi
- UGC, New Delhi
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Two different strategies were considered for the total synthesis of metacridamides A and B. The first approach based on Horner-Wittig olefination reaction was unsuccessful. The second approach, involving several reactions, successfully synthesized an advanced intermediate 39 with all stereocenters present in metacridamides A and B.
Two different strategies have been considered to achieve the total synthesis of metacridamides A and B. The first approach based on Horner-Wittig olefination reaction was unsuccessful. The second approach, involving desymmetrization, a highly diastereoselective aldolization, Wittig olefination, amide formation and finally tethering formation, furnished an advanced intermediate 39 with all stereocenters present in metacridamides A and B. (C) 2022 Published by Elsevier Ltd.
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