Recent advances in the chemistry of 1,2,4-triazoles: Synthesis, reactivity and biological activities

1,2,4-Triazoles are important heterocyclic motifs that are widely found in molecular architectures with medicinal and pharmaceutical properties. Considering the importance of these scaffolds, many works have been published over the last few decades. This review provides a focus on the synthetic approaches towards 1,2,4-triazole derivatives from common precursors such as amidines, imidates, amidrazones, aryldiazoniums and hydrazones over the last decade. This review also aims to provide an overview of triazole derivatives biological properties within the last two years. (c) 2021 Elsevier Ltd. All rights reserved.

Automated summary

1,2,4-Triazoles are important heterocyclic motifs widely present in molecular architectures with medicinal and pharmaceutical properties. This review focuses on synthetic approaches towards 1,2,4-triazole derivatives in the last decade and provides an overview of the biological properties of triazole derivatives in the last two years.