Journal
TETRAHEDRON LETTERS
Volume 93, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2022.153693
Keywords
Photocatalyst-free; Quinoxalin-2(1H)-ones; Visible light; Trifluoromethylation
Categories
Funding
- National Natural Science Foundation of China [21602046]
- MOST of China [2016YFE0132600]
- Henan Center for Outstanding Overseas Scientists [GZS2020001]
- Foundation for University Key Teachers from the Education Department of Henan Province [2020GGJS107]
- Key Scientific and Technological Project of Henan Province [212102311068]
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A visible light-induced C-H trifluoromethylation of quinoxalin-2(1H)-ones using CF3SO2Cl as the CF3 radical source under photocatalyst-free conditions is reported in this study. The reaction proceeds smoothly through a radical process in the absence of photocatalyst and oxidant, offering an efficient and green method for the synthesis of 3-trifluoromethyl quinoxalin-2(1H)-ones.
Reported herein is a visible light-induced C-H trifluoromethylation of quinoxalin-2(1H)-ones with CF3SO2Cl as CF3 radical source under photocatalyst-free conditions. The reaction proceeds smoothly through a radical process in the absence of photocatalyst and oxidant in moderate to good yields, thus offering an efficient and green method for the synthesis of 3-trifluoromethyl quinoxalin-2(1H)-ones.(C) 2022 Elsevier Ltd. All rights reserved.
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