4.4 Article

The synthesis and use of γ-chloro-enamides for the subsequent construction of novel enamide-containing small molecules

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Summary: In order to increase the reliability and success rate of drug discovery, researchers have developed a new method to synthesize drug-like alpha-branched chiral amines and derivatives by nickel-catalyzed asymmetric reductive hydroalkylation of enamides and enecarbamates.

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