Journal
TETRAHEDRON
Volume 106, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2022.132649
Keywords
Trifluoromethylthiolation; Dearomatization; Radical cascade cyclization; Alkynes
Categories
Funding
- Natural Science Foundation of the Jiangsu Higher Education Institutions of China [19KJB150020]
- Basic Research Project (Natural Science Foundation for Young Scholars) of Jiangsu Province, China [BK20200953]
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A direct and efficient strategy for the trifluoromethylthiolation and dearomatization of biaryl ynones with stable and readily available AgSCF3 has been developed. The reaction occurs smoothly in the presence of K2S2O8 via a 6-exo-trig radical cyclization, providing a variety of SCF3-containing spiro [5,5] trienones in good yields.
A direct and efficient strategy for the trifluoromethylthiolation and dearomatization of biaryl ynones with stable and readily available AgSCF3 has been developed. The reaction occurs smoothly in the presence of K2S2O8 via a 6-exo-trig radical cyclization, providing a variety of SCF3-containing spiro [5,5] trienones in good yields. (C) 2022 Elsevier Ltd. All rights reserved.
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