Enamines and their variants as intermediates for synthesis of aza-heterocycles with applications in MCRs

This review brings together the versatility of enamine intermediates and multicomponent reactions that have been coalesced to generate a diverse library of nitrogen containing heterocyclic compounds. The reactions and mechanistic pathways enumerated cover a wide range of aza-heterocycles like pyrroles, pyridines, triazoles, indoles and aza-spiro heterocycles that can be synthesized through in situ generated enamines as intermediates in multi component condensations. (c) 2021 Elsevier Ltd. All rights reserved.

Automated summary

A diverse library of nitrogen containing heterocyclic compounds can be synthesized through the versatility of enamine intermediates and multicomponent reactions.