Journal
TETRAHEDRON
Volume 103, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2021.132573
Keywords
Claisen condensation; Total synthesis; Natural products; Asymmetric synthesis
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Funding
- Alzahra University Research Council
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The Claisen condensation is a base-mediated reaction that generates alpha,beta-keto ester by reacting an ester with a molecule containing alpha-hydrogen atom. This review focuses on the applications of Claisen condensation in the total synthesis of natural products, covering relevant literature up to the beginning of 2021.
The Claisen condensation involves the base-mediated reaction of an ester including alpha-hydrogen atom with a similar molecule to generate alpha,beta-keto ester. In this review, we focused on the applications of the Claisen condensation in the total synthesis of natural products. The review covers the related literatures up to the beginning of 2021. (C) 2021 Published by Elsevier Ltd.
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