Solvent- and Metal-Controlled Regiodivergent Synthesis of Tri-fluoromethylated Pyrazol-3-yl- and Pyrazol-5-ylphosphonates

Convenient approaches to the selective syntheses of trifluoromethylated pyrazol-3-yl- and pyrazol-5-ylphosphonates have been developed based on solvent- and metal-controlled reaction of diethyl (4,4,4-trifluoro-3-oxobut-1-yn-1-yl)phosphonate and monosubstituted hydrazines.

Automated summary

Convenient methods for the selective synthesis of trifluoromethylated pyrazol-3-yl- and pyrazol-5-ylphosphonates have been developed using solvent and metal-controlled reactions.