Journal
SYNTHESIS-STUTTGART
Volume 54, Issue 5, Pages 1287-1300Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/a-1681-3972
Keywords
carboxylic amides; hydrogenation; imidoyl chlorides; frustrated Lewis pairs; tertiary amines; secondary amines
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Funding
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [PA 1562/18-1]
- Verband der Chemischen Industrie (VCI)
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The paper reviews the development of frustrated Lewis pair catalyzed hydrogenation of tertiary and secondary amides, as well as strategies to overcome challenges in the reaction development process. Furthermore, the chemistry is extended to the hydrogenation of polyamides and trifluoroacetamides for the introduction of trifluoroethyl groups into organic molecules.
The development of the frustrated Lewis pair catalyzed hydrogenation of tertiary and secondary amides is reviewed. Detailed insight into our strategies in order to overcome challenges during the reaction development process is provided. Furthermore, the developed chemistry is extended to the hydrogenation of polyamides and of trifluoroacetamides for the convenient introduction of trifluoroethyl groups into organic molecules.
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