Journal
SYNTHESIS-STUTTGART
Volume 54, Issue 5, Pages 1217-1230Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/a-1684-2942
Keywords
asymmetric synthesis; asymmetric catalysis; alkaloids; total synthesis; catalysis
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Funding
- National Institute of General Medical Sciences [R35GM136440]
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This article summarizes the research on the total synthesis of bioactive alkaloids, highlighting the importance and achievements of catalytic asymmetric methods in this field, and providing new inspiration for future synthesis of these important natural products.
The total synthesis of bioactive alkaloids is an enduring challenge and an indication of the state of the art of chemical synthesis. With the explosion of catalytic asymmetric methods over the past three decades, these compelling targets have been fertile proving grounds for enantioselective bond forming transformations. These activities are summarized herein both to highlight the power and versatility of these methods and to instill future inspiration for new syntheses of these privileged natural products.
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