Taking the Green Road Towards Pharmaceutical Manufacturing

The introduction of the Green Chemistry Principles in the late 1990s formed the basis for a transition to a greener environment. These Principles have become an integral part in the work on designing chemical processes, especially for large-scale manufacture. The ultimate target is the achievement of a sustainable production method allowing hundreds of tons of valuable materials to be prepared. For this purpose, a holistic view must be applied to the dements constituting a fully-fledged process encompassing layout of the synthetic route, defining starting materials and their origin, output of product and quality features, quantity of effluent streams and waste, recovery and recycling of chemicals involved, and energy consumption. These parameters form a complex matrix where the individual components are in a complicated relationship with each other. This short review addresses these issues and the benefits of life-cycle assessment and metrics commonly used to measure the performance of chemical manufacturing - all from a pharmaceutical industry perspective as experienced by the author.

Automated summary

This short review discusses the importance of the Green Chemistry Principles in designing chemical processes, particularly in the pharmaceutical industry. It also explores the use of life-cycle assessment and metrics to measure the performance of chemical manufacturing.