Enantioselective C-H Alkylation of N-Arylbenzamides with Vinyl Ethers Catalyzed by an Iridium/Chiral Phosphoramidite-Olefin Complex

Chiral phosphoramidite-olefin hybrid ligands were found to be effective in the iridium-catalyzed asymmetric alkylation of N-arylbenzamides with vinyl ethers. The reaction is catalyzed by a hydroxo-iridium catalyst coordinated with the hybrid ligand to give the corresponding products in high yields with high branch selectivity and enantioselectivity.

Automated summary

Chiral phosphoramidite-olefin hybrid ligands were effective in the iridium-catalyzed asymmetric alkylation of N-arylbenzamides with vinyl ethers. The reaction yield was high, with high branch selectivity and enantioselectivity.