Journal
SYNTHESIS-STUTTGART
Volume 54, Issue 3, Pages 741-753Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0041-1737275
Keywords
palladium; boronic acids; Suzuki-Miyaura reaction; indoles; benzofurans; diarylmethanes
Categories
Funding
- Progetti di Ricerca di Interesse Nazionale [PRIN 2017SXBSX4]
Ask authors/readers for more resources
The palladium-catalyzed synthesis of indole/benzofuran-containing diarylmethanes was investigated, showing that the choice of precatalyst is crucial for the success of the reaction. Different precatalysts were found to be more efficient for different substrates, leading to good to high yields. This methodology can be extended to the preparation of a key precursor of Zafirlukast.
The palladium-catalyzed synthesis of indole/benzofuran-containing diarylmethanes starting from indolylmethyl or benzofuranylmethyl acetates with boronic acids has been investigated. The success of the reaction is influenced by the choice of precatalyst: with indolylmethyl acetates the reaction works well with [Pd(eta (3) -C (3) H (5) )Cl] (2) /XPhos while with benzofuranylmethyl acetates Pd (2) (dba) (3) /XPhos is more efficient. The good to high yields and the simplicity of the experimental procedure make this protocol a versatile synthetic tool for the preparation of 2- and 3-substituted indoles and 2-benzo[ b ]furans. The methodology can be advantageously extended to the preparation of a key precursor of Zafirlukast.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available