Journal
INTERNAL MEDICINE
Volume 55, Issue 18, Pages 2663-2668Publisher
JAPAN SOC INTERNAL MEDICINE
DOI: 10.2169/internalmedicine.55.6726
Keywords
thrombospondin type-1 domain-containing 7A; membranous nephropathy; childbearing age; pregnancy
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A 30-year-old woman with proteinuria first noted at 26 weeks of gestation was admitted to undergo further evaluation. A renal biopsy revealed membranous nephropathy (MN). There was no evidence of any secondary MN. Prednisolone was initiated 6 months after delivery. Four months later, her urine protein became negative. Enhanced granular staining for thrombospondin type-1 domain-containing 7A (THSD7A) in the glomeruli was retrospectively detected in a biopsy specimen. A literature review revealed that 60% of cases of THSD7A-related MN occurred in women of childbearing age. Therefore, THSD7A-related MN should be considered in female patients presenting with idiopathic MN in childbearing age.
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