4.7 Editorial Material

How CEP164 ciliopathy mutations impair ciliogenesis

Journal

STRUCTURE
Volume 30, Issue 1, Pages 4-5

Publisher

CELL PRESS
DOI: 10.1016/j.str.2021.12.007

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In this study, the co-crystallized structures revealed the molecular mechanism of CEP164 recruiting TTBK2 to the distal end of centrioles and how ciliopathy mutations in CEP164 disrupt the CEP164-TTBK2 complex.
CEP164 recruits TTBK2 to the distal end of centrioles to allow primary cilium formation. In this issue of Structure, Rosa e Silva et al. (2022) present co-crystallized structures that show the molecular basis of this recruitment and define how ciliopathy mutations in CEP164 disrupt the CEP164-TTBK2 complex.

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