Organoid technology: Current standing and future perspectives

Organoids are powerful systems to facilitate the study of individuals' disorders and personalized treatments. Likewise, emerging this technology has improved the chance of translatability of drugs for preclinical therapies and mimicking the complexity of organs, while it proposes numerous approaches for human disease modeling, tissue engineering, drug development, diagnosis, and regenerative medicine. In this review, we outline the past/present organoid technology and summarize its faithful applications, then we discuss the challenges and limitations encountered by three-dimensional organoids. In the end, we offer the human organoids as basic mechanistic infrastructure for human modeling systems to prescribe personalized medicines.

Automated summary

Organoid technology is a powerful tool for personalized treatments and drug development, enabling the modeling of organ complexity and diseases. However, it also encounters challenges and limitations in its applications.