Journal
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Volume 267, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2021.120617
Keywords
NH2-UiO-66; AgNPs; Glutathione; Metal enhanced fluorescence; Fluorescence quenching
Categories
Funding
- National Natural Science Foundation of China [41867053]
- Science and Technol-ogy Research Project of Education Department of Jiangxi Province [GJJ190615]
- Natural Science Foundation of Jiangxi Pro-vince [20202BAB213018]
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A fluorescent nanosensor based on NH2-UiO-66 and AgNPs has been developed for sensitive and selective detection of glutathione (GSH) in human serum.
Herein, a fluorescent nanosensor has been constructed for detection of glutathione (GSH) based on NH2-UiO-66 and AgNPs. The NH2-UiO-66 was synthesized where 2-amino-terephthalic acid as the organic ligand and Zr4+ as the center metal ions. The AgNPs can enhance the fluorescence of NH2-UiO-66 based on metal enhanced fluorescence (MEF) effect. Moreover, in the present of GSH, the fluorescence of NH2- UiO-66@AgNPs was quenched via electrostatic interaction and Ag-S reaction. The present sensing strategy shows good linear relation with the concentration of GSH in the range of 0.2-1.0 mu M and 1.0-30 mu M, and the limit of detection is 79 nM. Furthermore, our fluorescent nanosensor was utilized to detect GSH in human serum with a recovery of 96.8-102.5%. The results indicated that NH2-UiO-66@AgNPs is successfully applied for high sensitive and selective detection of GSH in human serum. (c) 2021 Elsevier B.V. All rights reserved.
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