Journal
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Volume 265, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2021.120390
Keywords
Fluorescent probe; Hydrogen sulfide; Excited-state intramolecular proton transfer; Mitochondria-targeting
Categories
Funding
- Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi [2020L0545]
- Xinzhou Teachers University Fund [2019KY09]
- Xinzhou Teachers University PhD startup fund [00000460]
- Fund for Shanxi 1331 Project Key Subjects Construction
- Top Science and Technology Innovation Teams of Xinzhou Teachers University
Ask authors/readers for more resources
The designed fluorescent probe HBTP-H2S based on ESIPT effect showed fast response time, good selectivity and a large Stokes shift towards H2S, and was successfully employed to monitor mitochondrial H2S in HepG2 cells.
Excited-state intramolecular proton transfer (ESIPT) has recently received considerable attention due to its dual fluorescent changes and large Stokes shift. Hydrogen sulfide (H2S) is a gas signal molecule that plays important roles in modulating the functions of different systems. Herein, by modifying 2-(2-hydroxyphenyl) benzothiazole (HBT) scaffold, a novel near-infrared mitochondria-targeted fluorescent probe HBTP-H2S has been rationally designed based on excited-state intramolecular proton transfer (ESIPT) effect. The nucleophilic addition reaction of the H2S with probe HBTP-H2S caused the break of the conjugated skeleton, resulting the shifting of maximum emission peak from 658 nm to 470 nm. HBTP-H2S showed fast-response response time, good selectivity and a large Stokes shift (188 nm) toward H2S. Most importantly, inspired by the inherent advantages of the probe, HBTP-H2S was successfully employed to monitor mitochondrial H2S in HepG2 cells. (C) 2021 Published by Elsevier B.V.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available