Journal
SMALL
Volume 17, Issue 43, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202103780
Keywords
fluorescence imaging; optical coherence tomography; photoacoustic imaging; second near infrared window; vascular imaging
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Funding
- National Natural Science Foundation of China [51922111]
- Science and Technology Development Fund, Macau SAR [0124/2019/A3]
- Guangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional Materials [2019B121205002]
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This review summarizes the latest progress of NIR-II optical imaging for angiography, including fluorescence imaging, photoacoustic imaging, and optical coherence tomography. It highlights the optimization and application of probes in vascular imaging.
Optical imaging in the second near infrared region (NIR-II, 1000-1700 nm) provides higher resolution and deeper penetration depth for accurate and real-time vascular anatomy, blood dynamics, and function information, effectively contributing to the early diagnosis and curative effect assessment of vascular anomalies. Currently, NIR-II optical imaging demonstrates encouraging results including long-term monitoring of vascular injury and regeneration, real-time feedback of blood perfusion, tracking of lymphatic metastases, and imaging-guided surgery. This review summarizes the latest progresses of NIR-II optical imaging for angiography including fluorescence imaging, photoacoustic (PA) imaging, and optical coherence tomography (OCT). The development of current NIR-II fluorescence, PA, and OCT probes (i.e., single-walled carbon nanotubes, quantum dots, rare earth doped nanoparticles, noble metal-based nanostructures, organic dye-based probes, and semiconductor polymer nanoparticles), highlighting probe optimization regarding high brightness, longwave emission, and biocompatibility through chemical modification or nanotechnology, is first introduced. The application of NIR-II probes in angiography based on the classification of peripheral vascular, cerebrovascular, tumor vessel, and cardiovascular, is then reviewed. Major challenges and opportunities in the NIR-II optical imaging for vascular imaging are finally discussed.
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