Journal
SMALL
Volume 18, Issue 4, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202103541
Keywords
biomolecules; intrinsically flexible interactive electroluminescent displays; liquid electrodes; microfluidic chips; visual detection; visual quantification
Categories
Funding
- A*STAR SIMTech RPE funding [C18-A-037]
- Singapore Ministry of Education, Academic Research Fund Tier 1 [2019-T1-002-045, RG125/19]
- *STAR SERC AME Programmatic Fund [SERC A18A8b0059]
- Academic Research Fund Tier 2 [MOE2018-T2-2-042]
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This study presents a novel biomolecule-interactive flexible light emitting capacitor (LEC) display capable of dynamic and quantitative visualization of biomolecules through naked-eye detectable electroluminescence. The BIO-LEC features a simple stimuli response principle, no labeling requirement in test conditions, effective sampling method through an integrated microfluidic chip, sensitive detection limit for clinically relevant levels of heparin concentrations, and high compliance with industrial manufacturing standards.
Ultrathin, lightweight, flexible, and conformable interactive displays that transduce external stimuli into human-readable signals are essential for emerging applications, such as wearable electronics, human-machine interfaces, and soft robots. Herein, a biomolecule-interactive flexible light emitting capacitor (LEC) display (BIO-LEC) capable of dynamic and quantitative visualization of biomolecules through naked-eye detectable electroluminescence (EL) emission is reported. BIO-LEC comprises a coplanar LEC light source at the bottom, and a designed microfluidic chip as sampling compartment at the top. The quantitative measurement feature of BIO-LEC is achieved by introducing the top liquid electrode, which possesses a unique long dielectric realization time, in the microfluidic chip. BIO-LEC is novel for the following reasons, 1) simple stimuli response principle based on correlating EL intensity to dielectric properties of the top liquid electrode; 2) simple test conditions whereby no labeling is required in the analyte solution to optically detect biomolecules; 3) effective sampling method through the design of an integrated microfluidic chip for hosting the top liquid electrode, ensuring good reproducibility and preventing contamination; 4) sensitive detection limit for heparin concentrations at clinically relevant levels, and 5) high compliance with industrial manufacturing standards.
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