Journal
SMALL
Volume 18, Issue 3, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202104402
Keywords
anti-programmed cell death-1; biomimetic nanoparticles; cancer immunotherapy; cell membrane coating; cross-priming
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Funding
- National Key Research and Development Program of China [SQ2021YFA090162]
- National Natural Science Foundation of China [21875135]
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This study utilized cascade cell membrane coating to prepare biomimetic nanoparticles that can manipulate the cross-priming of T cells, leading to strong antitumor immune responses. Combination with clinical anti-programmed death-1 antibodies demonstrated the potential of this approach in enhancing tumor regression and survival rate.
Despite the activation of T lymphocytes by antigen-presenting cells being responsible for eliciting antigen-specific immune responses, their crosstalking suffers from temporospatial limitations and endogenous influencing factors, which restrict the generation of a strong antitumor immunity. Here, cascade cell membrane coating is reported to prepare biomimetic nanoparticles (BNs) that can manipulate the cross-priming of T cells. BNs are obtained from coating nanoparticulate substrates with cell membranes extracted from dendritic cells (DCs) that are pre-pulsed with cancer cell membrane-coated nanoparticles. With a DC membrane that presents an array of cancer cell membrane antigen epitopes, BNs inherit the intrinsic membrane function of DCs, which can directly cross-prime T cells and provoke robust yet antigen-specific antitumor responses in multiple mouse models. Combination with clinical anti-programmed death-1 antibodies demonstrates a robust way of BNs to achieve desirable tumor regression and survival rate. This work spotlights the impact of nanoparticles on direct cross-priming of T cells and supports a unique yet modulate platform for boosting an effective adaptive immunity for immunotherapy.
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