Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 350, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2021.130831
Keywords
Fluorescent probe; Hydrogen peroxide; Near-infrared; Selective detection
Funding
- key project of school of basic medical sciences in Xinxiang Medical University [JCYXYKY202019, JCYXYKY202020]
- Henan Students' Platform For Innovation And Entrepreneurship Training Program [S202110472031]
- Key Scientific Research Foundation of the Higher Education Institutions of Henan Province, China [21B350002]
- Natural Science Foundation of Henan Province [202300410322212300410222]
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This study developed a turn-on fluorescent probe, TMN-H2O2, with near-infrared emission for H2O2 detection in living systems, showing high selectivity, sensitivity, and fast response time. The successful application of TMN-H2O2 in vitro and in vivo suggests it is a reliable chemical tool for monitoring both endogenous and exogenous H2O2.
In this study, we report the construction of a turn-on fluorescent probe, TMN-H2O2 with near-infrared emission for H2O2 detection in living systems. A series of experiments demonstrated that TMN-H2O2 exhibits a high selectivity for H2O2. After reaction with H2O2, TMN-H2O2 exhibited a 14.3-fold increase in fluorescence intensity at 660 nm and a 180 nm large Stokes shift. Moreover, TMN-H2O2 exhibited excellent sensitivity (limit of detection: 76 nM) and a fast response time (similar to 40 min). The successful in vitro and in vivo application of TMN-H2O2 therefore suggested that this probe is a reliable chemical tool for monitoring both endogenous and exogenous H2O2.
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