Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 345, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2021.130378
Keywords
Upconversion-based nanosensor; Dual-mode probe; Visual quantitative sensing; Smartphone-sensing platform; Heparin
Funding
- National Natural Science Foundation of China [21671052, 21806168]
- Key Research and Development Program of Anhui Province [202004d07020013, 1804a07020103]
Ask authors/readers for more resources
A nano sensor based on UCNPs was developed for the sensitive detection of heparin, with low detection limits in fluorescent and colorimetric modes. Additionally, quantitative detection of heparin can be performed using a smartphone sensing platform, providing convenience for practical applications.
Heparin is an important anticoagulant in clinics, which requires regular detection and dose adjustment. Fluo-rimetry is a powerful tool considering the advantages of fast response and high sensitivity while most fluorescent sensors suffer from spontaneous fluorescence for excitation under short-wavelength light, the occurrence of false positives, complex and time-consuming preparation, as well as expensive detection instruments. Herein, we developed upconversion nanoparticles (UCNPs) based nanosensor for fluorescent and colorimetric detection of heparin. The nanosensor exhibited sensitive detection for heparin with the low limit of detection (LOD) of 0.1 nM in fluorescent mode and 0.3 nM in colorimetric mode. In addition, we used a smartphone-sensing platform for quantitative detection of heparin with the LOD of 2 nM. Depending on long-wavelength excitation and fluorescent-colorimetric dual-response detection signal, the designed nanosensor could eliminate the auto-fluorescence, which effectively increased the accuracy of the sensor, thus extending the applications for bed -side heparin assay and related medical safety.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available