4.7 Review

Recent advance in cell patterning techniques: Approaches, applications and future prospects

Journal

SENSORS AND ACTUATORS A-PHYSICAL
Volume 333, Issue -, Pages -

Publisher

ELSEVIER SCIENCE SA
DOI: 10.1016/j.sna.2021.113229

Keywords

Cell patterning; Microfluidic; Cell behavior

Funding

  1. National Key R&D Program of China [2018YFB1304904]
  2. National Natural Science Foundation of China [61803323]
  3. Shandong Province Natural Science Foundation [ZR2019BF049]
  4. Key Research Program of Frontier Science [QYZDB-SSW-JSC008]
  5. Science & Technology Department of Liaoning Province [2021-KF-22-03]
  6. State Key Laboratory of Robotics [2021-KF-22-03]

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Cell patterning technology is an effective technique for understanding cell behaviors by controlling the position of cells. It has led to the development of various micro-nano manufacturing methods, including stencil patterning, microfluidics-based techniques, and surface modification techniques. Cell patterning has wide applications and future prospects in biological research.
Cell patterning technology is an effective technique to understand cell behaviors by precisely controlling the position of cells revealing the major contributions of cells in basic and applied biological research in vitro. Therefore, this technology has led to the development of various micro-nano manufacturing methods. In recent years, various methods have been continuously improved and innovated based on existing methods to overcome shortcomings. We outline the latest developments in cell patterning technology, including stencil patterning, microfluidics-based on traps and droplets, and surface modification techniques such as photolithography, microcontact printing, and laser technology. In the end, we introduce the application and future prospects of cell patterning in biological research.(c) 2021 Elsevier B.V. All rights reserved.

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