4.6 Review

Microscopies Enabled by Photonic Metamaterials

Journal

SENSORS
Volume 22, Issue 3, Pages -

Publisher

MDPI
DOI: 10.3390/s22031086

Keywords

photonic metamaterials; microscopy; plasmonic; photonic crystals; label-free; fluorescence; biomolecular detection; biosensor

Funding

  1. National Institutes of Health (NIH) [CA227699, EB029805]
  2. National Science Foundation (NSF) [CBET 1900277, RAPID 2027778]
  3. NSFC normal grant of China [61974128, 21874116]
  4. Natural Science Foundation of Zhejiang Province [LY19F040007]
  5. Cancer Scholars for Translational and Applied Research (C*STAR) from Cancer Center at Illinois
  6. Center of Pathogen Diagnostics in the Dynamic Research Enterprise for Multidisciplinary Engineering Sciences (DREMES) at Zhejiang University
  7. University of Illinois at Urbana-Champaign
  8. CSL Behring LLC
  9. Cyrus Tang Foundation
  10. Dr. Li Dak Sum & Yip Yio Chin Development Fund for Regenerative Medicine of Zhejiang University
  11. [2027778]

Ask authors/readers for more resources

The development of nanostructured materials in biosensor research has made significant progress in amplifying the interaction between light and biological matter, providing new solutions for enhancing contrast and signal-to-noise ratio in microscopy.
In recent years, the biosensor research community has made rapid progress in the development of nanostructured materials capable of amplifying the interaction between light and biological matter. A common objective is to concentrate the electromagnetic energy associated with light into nanometer-scale volumes that, in many cases, can extend below the conventional Abbe diffraction limit. Dating back to the first application of surface plasmon resonance (SPR) for label-free detection of biomolecular interactions, resonant optical structures, including waveguides, ring resonators, and photonic crystals, have proven to be effective conduits for a wide range of optical enhancement effects that include enhanced excitation of photon emitters (such as quantum dots, organic dyes, and fluorescent proteins), enhanced extraction from photon emitters, enhanced optical absorption, and enhanced optical scattering (such as from Raman-scatterers and nanoparticles). The application of photonic metamaterials as a means for enhancing contrast in microscopy is a recent technological development. Through their ability to generate surface-localized and resonantly enhanced electromagnetic fields, photonic metamaterials are an effective surface for magnifying absorption, photon emission, and scattering associated with biological materials while an imaging system records spatial and temporal patterns. By replacing the conventional glass microscope slide with a photonic metamaterial, new forms of contrast and enhanced signal-to-noise are obtained for applications that include cancer diagnostics, infectious disease diagnostics, cell membrane imaging, biomolecular interaction analysis, and drug discovery. This paper will review the current state of the art in which photonic metamaterial surfaces are utilized in the context of microscopy.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available