Journal
SEMINARS IN IMMUNOPATHOLOGY
Volume 43, Issue 5, Pages 657-668Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00281-021-00871-y
Keywords
IgA nephropathy; Mucosal immunity; Gut-kidney axis; Tonsil-kidney axis; Microbiota; Diet
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Funding
- Universita degli Studi di Bari Aldo Moro within the CRUI-CARE Agreement
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The pathogenesis of IgA nephropathy may be associated with mucosal immunity, microbiota, genetic factors, food antigens, infections, and mucosal immune response. Potential therapies targeting microbes and mucosal hyperresponsiveness in IgAN patients are currently being evaluated.
The precise pathogenesis of immunoglobulin A nephropathy (IgAN) is still not clearly established but emerging evidence confirms a pivotal role for mucosal immunity. This review focuses on the key role of mucosa-associated lymphoid tissue (MALT) in promoting the onset of the disease, underlying the relationship among microbiota, genetic factors, food antigen, infections, and mucosal immune response. Finally, we evaluate potential therapies targeting microbes and mucosa hyperresponsiveness in IgAN patients.
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