Journal
SEMINARS IN FETAL & NEONATAL MEDICINE
Volume 26, Issue 5, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.siny.2021.101304
Keywords
Advanced MRI techniques; Asphyxia; Diffusion-tensor imaging; Diffusion-weighted imaging; Hypoxic-ischemic brain injury; Magnetic resonance spectroscopy imaging; Neonatal encephalopathy; Neonates; Outcome prediction; Predictive values
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Funding
- National Institutes of Health [K23HD099309, U01NS092764]
- FRSQ
- Canadian Institutes of Health Research (CIHR)
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This review outlines the primary patterns of brain injury associated with hypoxic-ischemic injury in neonates with NE and their frequency, associated neuropathological features, and risk factors. It provides an overview of neuroimaging methods, including the most widely used scoring systems used to characterize brain injury in these neonates and their utility as predictive biomarkers. Recommendations for neuroimaging in neonates with NE are also presented.
Neuroimaging is widely used to aid in the diagnosis and clinical management of neonates with neonatal encephalopathy (NE). Yet, despite widespread use clinically, there are few published guidelines on neuroimaging for neonates with NE. This review outlines the primary patterns of brain injury associated with hypoxic-ischemic injury in neonates with NE and their frequency, associated neuropathological features, and risk factors. In addition, it provides an overview of neuroimaging methods, including the most widely used scoring systems used to characterize brain injury in these neonates and their utility as predictive biomarkers. Last, recommendations for neuroimaging in neonates with NE are presented.
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