Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 126, Issue -, Pages 99-107Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2021.11.005
Keywords
TRIM21; Antibody; Trim-Away; Intracellular neutralization; Virus; E3 ubiquitin ligase
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Funding
- Boehringer Ingelheim Fonds (Germany)
- MRC (UK) [U105181010]
- Wellcome Trust Investigator Award (UK)
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This paper reviews how TRIM21 degrades diverse targets and how this activity can be applied in molecular biology and new therapeutic development. In addition, it compares TRIM21's mechanism to other TRIM proteins and RING E3 ligases.
The cytosolic antibody receptor and RING E3 ligase TRIM21 targets intracellular, antibody-coated immune complexes for degradation and activates the immune system. Here we review how TRIM21 degrades diverse targets and how this activity can be exploited in molecular biology and for the development of new therapeutics. In addition, we compare what is known about TRIM21 ' s mechanism to other TRIM proteins and RING E3 ligases.
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