4.6 Review

Ubiquitin-chains dynamics and its role regulating crucial cellular processes

Related references

Note: Only part of the references are listed.
Review Cell Biology

K27-linked noncanonic ubiquitination in immune regulation

Qingqing Zhou et al.

Summary: The role of K27-linked noncanonic ubiquitination is crucial in regulating immune responses, including antimicrobial response, cytokine signaling, and T cell activation and differentiation. Further investigations are needed to better understand the mechanisms of noncanonic ubiquitination.

JOURNAL OF LEUKOCYTE BIOLOGY (2022)

Review Cell Biology

RIPK1 ubiquitination: Evidence, correlations and the undefined

Daniel S. Simpson et al.

Summary: Over the last two decades, research has focused on understanding the role of RIPK1 in cell survival and death pathways, particularly its involvement in NF-kappa B signaling and cell death processes. However, the specific impact of RIPK1 ubiquitination on signaling outcomes remains unclear due to the complexity of ubiquitin signaling.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Inhibition of the proteasome and proteaphagy enhances apoptosis in FLT3-ITD-driven acute myeloid leukemia

Rosa G. Lopez-Reyes et al.

Summary: The study found that proteasome inhibition in acute myeloid leukemia cells expressing the FLT3-ITD mutation leads to proteaphagy, while no such phenomenon occurs in cells with wild-type FLT3. Additionally, the crosstalk between proteasome and autophagy is mediated through the ubiquitin pathway.

FEBS OPEN BIO (2021)

Review Cell Biology

Emerging functions of branched ubiquitin chains

Michael E. French et al.

Summary: Ubiquitylation is a critical post-translational modification that controls various cellular processes. Different topologies of ubiquitin chains regulate the stability, activity, interaction properties, and localization of proteins. Recent studies have shown that branched ubiquitin chains play a role in cell signaling and protein degradation pathways, with diverse chemical linkages and structures.

CELL DISCOVERY (2021)

Article Biochemistry & Molecular Biology

The UBA domain of conjugating enzyme Ubc1/Ube2K facilitates assembly of K48/K63-branched ubiquitin chains

Lukas Pluska et al.

Summary: The assembly of specific polymeric ubiquitin chains on target proteins is crucial for regulating cellular processes, but the mechanisms behind selective synthesis of these chains remain unclear. The E2 enzymes Ubc1 and Ube2K interact preferentially with ubiquitin chains linked through lysine 63 (K63), facilitating the selective assembly of K48/K63-branched ubiquitin conjugates. The activity of the UBA domain in these enzymes is linked to cellular proteostasis maintenance.

EMBO JOURNAL (2021)

Article Biochemistry & Molecular Biology

BRCA1/BARD1 site-specific ubiquitylation of nucleosomal H2A is directed by BARD1

Samuel R. Witus et al.

Summary: Mutations in the RING domains of the E3 ubiquitin ligase BRCA1/BARD1 increase the risk of breast and ovarian cancers. The structure of the BRCA1/BARD1 RING heterodimer with UbcH5c bound to the nucleosome, along with biochemical data, explains how the complex selectively ubiquitylates specific lysines in H2A. The findings provide insight into how E3 ligases target lysine residues in nucleosomes and how mutations in cancer patients affect this process.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2021)

Review Immunology

OTULIN in NF-KB signaling, cell death, and disease

Lien Verboom et al.

Summary: Tight control of inflammatory signaling pathways is essential to prevent chronic inflammation and disease. OTULIN, a protein responsible for such control, plays a critical role in regulating inflammation and has been linked to the development of inflammatory diseases. Additionally, OTULIN has been found to have several newly identified roles, including a ubiquitinindependent function.

TRENDS IN IMMUNOLOGY (2021)

Article Cell Biology

A20 at the Crossroads of Cell Death, Inflammation, and Autoimmunity

Arne Martens et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2020)

Article Biochemical Research Methods

Analysis of ubiquitin signaling and chain topology cross-talk

Marta L. Mendes et al.

JOURNAL OF PROTEOMICS (2020)

Article Multidisciplinary Sciences

Gene expression and cell identity controlled by anaphase-promoting complex

Eugene Oh et al.

NATURE (2020)

Editorial Material Biochemistry & Molecular Biology

Getting Close: Insight into the Structure and Function of K11/K48-Branched Ubiquitin Chains

Regina Baur et al.

STRUCTURE (2020)

Review Cell Biology

The Role of Atypical Ubiquitin Chains in the Regulation of the Antiviral Innate Immune Response

Mariska van Huizen et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Review Chemistry, Multidisciplinary

Linear Ubiquitin Chains: Cellular Functions and Strategies for Detection and Quantification

Gunnar Dittmar et al.

FRONTIERS IN CHEMISTRY (2020)

Review Chemistry, Multidisciplinary

Hybrid Chains: A Collaboration of Ubiquitin and Ubiquitin-Like Modifiers Introducing Cross-Functionality to the Ubiquitin Code

David A. Perez Berrocal et al.

FRONTIERS IN CHEMISTRY (2020)

Review Cell Biology

IAP-Mediated Protein Ubiquitination in Regulating Cell Signaling

Baptiste Dumetier et al.

CELLS (2020)

Review Medicine, General & Internal

Neddylation: A Versatile Pathway Takes on Chronic Liver Diseases

Jiping Yao et al.

FRONTIERS IN MEDICINE (2020)

Review Biochemistry & Molecular Biology

Resolving the Complexity of Ubiquitin Networks

Katarzyna Kliza et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2020)

Review Biochemistry & Molecular Biology

Cracking the Ubiquitin Code: The Ubiquitin Toolbox

Monique P. C. Mulder et al.

CURRENT ISSUES IN MOLECULAR BIOLOGY (2020)

Article Medicine, Research & Experimental

OTULIN deficiency in ORAS causes cell type-specific LUBAC degradation, dysregulated TNF signalling and cell death

Rune Busk Damgaard et al.

EMBO MOLECULAR MEDICINE (2019)

Review Cell Biology

Breaking the chains: deubiquitylating enzyme specificity begets function

Michael J. Clague et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Review Biochemistry & Molecular Biology

Using Ubiquitin Binders to Desipher the Ubiquitin Code

Michael Mattern et al.

TRENDS IN BIOCHEMICAL SCIENCES (2019)

Article Multidisciplinary Sciences

K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling

Qing Yin et al.

NATURE COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

RNF34 functions in immunity and selective mitophagy by targeting MAVS for autophagic degradation

Xiang He et al.

EMBO JOURNAL (2019)

Article Biochemistry & Molecular Biology

Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation

Julius Rabl et al.

MOLECULAR CELL (2019)

Article Multidisciplinary Sciences

Insights into ubiquitin chain architecture using Ub-clipping

Kirby N. Swatek et al.

NATURE (2019)

Review Biochemistry & Molecular Biology

Cellular functions and molecular mechanisms of non-lysine ubiquitination

Amie J. McClellan et al.

OPEN BIOLOGY (2019)

Review Biochemistry & Molecular Biology

A Diversity of Selective Autophagy Receptors Determines the Specificity of the Autophagy Pathway

Vladimir Kirkin et al.

MOLECULAR CELL (2019)

Review Cell Biology

Ubiquitin-mediated regulation of autophagy

Ruey-Hwa Chen et al.

JOURNAL OF BIOMEDICAL SCIENCE (2019)

Review Cell Biology

The role of K63-linked polyubiquitination in cardiac hypertrophy

Kaowen Yan et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2018)

Review Biochemistry & Molecular Biology

The Many Roles of Ubiquitin in NF-κB Signaling

Gilles Courtois et al.

BIOMEDICINES (2018)

Article Biochemistry & Molecular Biology

Zinc starvation induces autophagy in yeast

Tomoko Kawamata et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Review Oncology

Regulation of various DNA repair pathways by E3 ubiquitin ligases

Chandramouli Natarajan et al.

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS (2017)

Article Biochemistry & Molecular Biology

RNF8-and Ube2S-Dependent Ubiquitin Lysine 11-Linkage Modification in Response to DNA Damage

Atanu Paul et al.

MOLECULAR CELL (2017)

Article Biochemistry & Molecular Biology

Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling

Martin A. Michel et al.

MOLECULAR CELL (2017)

Article Multidisciplinary Sciences

Polyglutamine tracts regulate beclin 1-dependent autophagy

Avraham Ashkenazi et al.

NATURE (2017)

Review Biochemistry & Molecular Biology

Emerging Mechanisms in Initiating and Terminating Autophagy

Manuela Antonioli et al.

TRENDS IN BIOCHEMICAL SCIENCES (2017)

Review Biochemistry & Molecular Biology

TRIM Family Proteins: Roles in Autophagy, Immunity, and Carcinogenesis

Shigetsugu Hatakeyama

TRENDS IN BIOCHEMICAL SCIENCES (2017)

Article Multidisciplinary Sciences

USP13 negatively regulates antiviral responses by deubiquitinating STING

He Sun et al.

NATURE COMMUNICATIONS (2017)

Article Biochemistry & Molecular Biology

Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control

Richard G. Yau et al.

Review Genetics & Heredity

Histone ubiquitination in the DNA damage response

Michael Uckelmann et al.

DNA REPAIR (2017)

Review Immunology

The non-canonical NF-κB pathway in immunity and inflammation

Shao-Cong Sun

NATURE REVIEWS IMMUNOLOGY (2017)

Review Biochemistry & Molecular Biology

CYLD, A20 and OTULIN deubiquitinases in NF-κB signaling and cell death: so similar, yet so different

Marie Lork et al.

CELL DEATH AND DIFFERENTIATION (2017)

Review Biochemistry & Molecular Biology

Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

Roel Nusse et al.

Review Biochemistry & Molecular Biology

The Logic of the 26S Proteasome

Galen Andrew Collins et al.

Article Biochemistry & Molecular Biology

Starvation Induces Proteasome Autophagy with Different Pathways for Core and Regulatory Particles

Kenrick A. Waite et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Cell Biology

Autoubiquitination of TRIM26 links TBK1 to NEMO in RLR-mediated innate antiviral immune response

Yong Ran et al.

JOURNAL OF MOLECULAR CELL BIOLOGY (2016)

Review Cell Biology

Ubiquitin modifications

Kirby N. Swatek et al.

CELL RESEARCH (2016)

Review Biochemistry & Molecular Biology

NFKB1: a suppressor of inflammation, ageing and cancer

Tyrell Cartwright et al.

FEBS JOURNAL (2016)

Article Cell Biology

USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response

Zhiquan Wang et al.

GENES & DEVELOPMENT (2016)

Article Biochemistry & Molecular Biology

The Lys63-deubiquitylating Enzyme BRCC36 Limits DNA Break Processing and Repair

Hoi-Man Ng et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Cell Biology

Fine-tuning of ULK1 mRNA and protein levels is required for autophagy oscillation

Francesca Nazio et al.

JOURNAL OF CELL BIOLOGY (2016)

Article Biochemistry & Molecular Biology

USP38 Inhibits Type I Interferon Signaling by Editing TBK1 Ubiquitination through NLRP4 Signalosome

Meng Lin et al.

MOLECULAR CELL (2016)

Article Biochemistry & Molecular Biology

SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling

Paul R. Elliott et al.

MOLECULAR CELL (2016)

Article Biochemistry & Molecular Biology

The K48-K63 Branched Ubiquitin Chain Regulates NF-κB Signaling

Fumiaki Ohtake et al.

MOLECULAR CELL (2016)

Article Multidisciplinary Sciences

p62-and ubiquitin-dependent stress-induced autophagy of the mammalian 26S proteasome

Victoria Cohen-Kaplan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Review Cell Biology

Ubiquitin-Dependent And Independent Signals In Selective Autophagy

Aliaksandr Khaminets et al.

TRENDS IN CELL BIOLOGY (2016)

Article Biochemistry & Molecular Biology

Assembly and structure of Lys(33)-linked polyubiquitin reveals distinct conformations

Yosua Adi Kristariyanto et al.

BIOCHEMICAL JOURNAL (2015)

Article Biochemistry & Molecular Biology

KPC1-Mediated Ubiquitination and Proteasomal Processing of NF-κB1 p105 to p50 Restricts Tumor Growth

Yelena Kravtsova-Ivantsiv et al.

Article Biochemistry & Molecular Biology

K29-Selective Ubiquitin Binding Domain Reveals Structural Basis of Specificity and Heterotypic Nature of K29 Polyubiquitin

Yosua Adi Kristariyanto et al.

MOLECULAR CELL (2015)

Article Biochemistry & Molecular Biology

Autophagic Degradation of the 26S Proteasome Is Mediated by the Dual ATG8/Ubiquitin Receptor RPN10 in Arabidopsis

Richard S. Marshall et al.

MOLECULAR CELL (2015)

Article Biochemistry & Molecular Biology

Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function

Elton Zeqiraj et al.

MOLECULAR CELL (2015)

Article Biochemistry & Molecular Biology

Assembly and Specific Recognition of K29-and K33-Linked Polyubiquitin

Martin A. Michel et al.

MOLECULAR CELL (2015)

Article Multidisciplinary Sciences

Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage

Tina Thorslund et al.

NATURE (2015)

Article Multidisciplinary Sciences

Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy

Alban Ordureau et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Virology

Ubiquitination in the antiviral immune response

Meredith E. Davis et al.

VIROLOGY (2015)

Article Cell Biology

RNF168 Promotes Noncanonical K27 Ubiquitination to Signal DNA Damage

Marco Gatti et al.

CELL REPORTS (2015)

Article Cell Biology

SUMO1 promotes Aβ production via the modulation of autophagy

Sun-Jung Cho et al.

AUTOPHAGY (2015)

Review Immunology

Ubiquitin-mediated NFκB degradation pathway

Huimin Xu et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2015)

Article Biochemistry & Molecular Biology

Enhanced Protein Degradation by Branched Ubiquitin Chains

Hermann-Josef Meyer et al.

Article Cell Biology

Novel Lys63-linked ubiquitination of IKKb induces STAT3 signaling

Leandro H. Gallo et al.

CELL CYCLE (2014)

Article Cell Biology

AMBRA1 Interplay with Cullin E3 Ubiquitin Ligases Regulates Autophagy Dynamics

Manuela Antonioli et al.

DEVELOPMENTAL CELL (2014)

Article Biochemistry & Molecular Biology

Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner

Anja Bremm et al.

EMBO REPORTS (2014)

Article Cell Biology

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

Lesley A. Kane et al.

JOURNAL OF CELL BIOLOGY (2014)

Article Medicine, Research & Experimental

EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis

Haizhong Feng et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Editorial Material Biochemistry & Molecular Biology

PINK1-PARKIN Interplay: Down to Ubiquitin Phosphorylation

Alexandra Stolz et al.

MOLECULAR CELL (2014)

Article Biochemistry & Molecular Biology

K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking

Wei-Chien Yuan et al.

MOLECULAR CELL (2014)

Article Multidisciplinary Sciences

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

Baris Bingol et al.

NATURE (2014)

Editorial Material Cell Biology

AMPK connects energy stress to PIK3C3/VPS34 regulation

Joungmok Kim et al.

AUTOPHAGY (2013)

Review Immunology

Regulation of NF-κB by ubiquitination

Jueqi Chen et al.

CURRENT OPINION IN IMMUNOLOGY (2013)

Article Biochemistry & Molecular Biology

Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?

James A. Nathan et al.

EMBO JOURNAL (2013)

Editorial Material Pharmacology & Pharmacy

Non-canonical IKKs, IKKε and TBK1, as novel therapeutic targets in the treatment of non-small cell lung cancer

Jae-Young Kim et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2013)

Review Biochemistry & Molecular Biology

Linear ubiquitination-mediated NF-κB regulation and its related disorders

Fuminori Tokunaga

JOURNAL OF BIOCHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Smurf1-Mediated Lys29-Linked Nonproteolytic Polyubiquitination of Axin Negatively Regulates Wnt/β-Catenin Signaling

Cong Fei et al.

MOLECULAR AND CELLULAR BIOLOGY (2013)

Article Multidisciplinary Sciences

53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark

Amelie Fradet-Turcotte et al.

NATURE (2013)

Article Multidisciplinary Sciences

OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3

Hongbo Hu et al.

NATURE (2013)

Article Cell Biology

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

Ryan C. Russell et al.

NATURE CELL BIOLOGY (2013)

Article Multidisciplinary Sciences

Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy

Yonghua Yang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

Christoph H. Emmerich et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Cell Biology

Identification of the NF-κB inhibitor A20 as a key regulator for human adipogenesis

A. Dorronsoro et al.

CELL DEATH & DISEASE (2013)

Article Biochemistry & Molecular Biology

Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1

Harald W. Platta et al.

BIOCHEMICAL JOURNAL (2012)

Review Biochemistry & Molecular Biology

TAK1, more than just innate immunity

Liang Dai et al.

IUBMB LIFE (2012)

Article Multidisciplinary Sciences

CYLD negatively regulates transforming growth factor-β-signalling via deubiquitinating Akt

Jae Hyang Lim et al.

NATURE COMMUNICATIONS (2012)

Review Cell Biology

Non-canonical NF-kappa B signaling pathway

Shao-Cong Sun

CELL RESEARCH (2011)

Article Biochemistry & Molecular Biology

BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins

Martin Gamerdinger et al.

EMBO REPORTS (2011)

Article Multidisciplinary Sciences

Linear ubiquitination prevents inflammation and regulates immune signalling

Bjoern Gerlach et al.

NATURE (2011)

Article Biochemical Research Methods

Protein standard absolute quantification (PSAQ) method for the measurement of cellular ubiquitin pools

Stephen E. Kaiser et al.

NATURE METHODS (2011)

Article Multidisciplinary Sciences

α-Synuclein fate is determined by USP9X-regulated monoubiquitination

Ruth Rott et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Biochemistry & Molecular Biology

Ubiquitin: Same Molecule, Different Degradation Pathways

Michael J. Clague et al.

Article Biochemistry & Molecular Biology

HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy

Joo-Yong Lee et al.

EMBO JOURNAL (2010)

Article Biochemistry & Molecular Biology

Parkin Mono-ubiquitinates Bcl-2 and Regulates Autophagy

Dong Chen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Multidisciplinary Sciences

Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense

Kei-ichiro Arimoto et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Biochemistry & Molecular Biology

TRAF6 and A20 Regulate Lysine 63-Linked Ubiquitination of Beclin-1 to Control TLR4-Induced Autophagy

Chong-Shan Shi et al.

SCIENCE SIGNALING (2010)

Article Cell Biology

Signaling to NF-κB: Regulation by Ubiquitination

Ingrid E. Wertz et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Phosphorylation of the Tumor Suppressor CYLD by the Breast Cancer Oncogene IKKε Promotes Cell Transformation

Jessica E. Hutti et al.

MOLECULAR CELL (2009)

Article Biochemistry & Molecular Biology

A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates

Vladimir Kirkin et al.

MOLECULAR CELL (2009)

Article Multidisciplinary Sciences

Direct activation of protein kinases by unanchored polyubiquitin chains

Zong-Ping Xia et al.

NATURE (2009)

Article Multidisciplinary Sciences

The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation

Wei-Lei Yang et al.

SCIENCE (2009)

Article Multidisciplinary Sciences

Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains

Yusuke Sato et al.

NATURE (2008)

Article Biochemistry & Molecular Biology

MARCH-V is a novel mitofusin 2-and Drp1-binding protein able to change mitochondrial morphology

Nobuhiro Nakamura et al.

EMBO REPORTS (2006)

Article Cell Biology

Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology

Donald S. Kirkpatrick et al.

NATURE CELL BIOLOGY (2006)